Microglia that express the Alzheimer's associated APOE4 genetic variant are unable to effectively metabolize lipids. This causes lipids to build up, promoting inflammation and preventing effective neurotransmission.
People with the Alzheimer's associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developing severe coronavirus symptoms compared to those who those with the common e3e3 form of the APOE gene.
Researchers have successfully created a new, light sensitive, plant-human hybrid protein that efficiently modulates calcium channels.
Neuronal damage can begin up to twenty years before Alzheimer's symptoms appear, researchers report.
Gene involved in dementia affects the insulin pathway, reports biology professor Chris Li and colleagues. In recent years it became...
Low body mass index does not appear to be a causal risk factor for developing Alzheimer's disease, a new study reports.
Self-propagating amyloid and tau act as prions in the pathology of Alzheimer's disease. Higher levels of the prions in human brain samples were strongly correlated with early onset of Alzheimer's and death at a younger age.
Alzheimer Plagues in 3d – Swiss researchers succeeded in generating detailed three-dimensional images of the spatial distribution of amyloid plaques...
Researchers reveal the Bace1 protein, well known for its role in Alzheimer's disease, controls spindle development in muscles and leads to impaired movement when absent.
Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta.
Researchers report an MRI test to measure smaller volumes in specific hippocampal regions could be used to detect Alzheimer's disease.
A new study reports people may lose awareness of their memory loss almost three years prior to Alzheimer's disease setting in.
