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alpha-synuclein

·July 7, 2022·4 min read

Copper Leads to Protein Aggregation in Parkinson’s Disease

Alpha-synuclein proteins form into unusual shapes when exposed to large quantities of copper ions. Researchers say the effect of environmental copper exposure on alpha-synuclein could play a role in the pathogenesis of Parkinson's disease.

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·February 16, 2020·4 min read

Cough syrup drug being trialed as Parkinson’s treatment

Ambroxol, a medication approved to treat coughs, may slow the progression of Parkinson's disease. The medication is able to effectively cross the blood-brain barrier and increases levels of GCase in patients' brains. Ambroxol also appears to reduce Parkinson's-related alpha-synuclein levels.

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·December 14, 2021·3 min read

COVID Protein Interacts With Parkinson’s Protein, Promotes Amyloid Formation

The COVID causing SARS-CoV-2 protein interacts with alpha-synuclein, speeding up the formation of amyloid plaques, a new study reports.

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·June 5, 2017·4 min read

CRISPR Leads to New Screening Tool for Parkinson’s

CRISPR technology allows researchers to illuminate and monitor alpha synuclein in the brain.

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·January 10, 2019·4 min read

Defective Glial Cells Can Push Neurons Toward Parkinson’s Disease

A new study reveals a defective version of astrocytes may be linked to the build up of alpha synuclein and could spur Parkinson's disease. The findings show the important role glial cells play in Parkinson's and offers insights into new targets for therapies to fight the neurodegenerative disease.

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·July 29, 2019·4 min read

Discovery could lead to new treatments for Parkinson’s, other brain diseases

New model could inform the development of new treatments for Lewy body diseases by targeting alpha-synuclein DNA repair mechanisms.

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·July 19, 2016·6 min read

Discovery May Lead to a Treatment to Slow Parkinson’s

Researchers have discovered an interaction in neurons that contributes to Parkinson's disease.

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·May 19, 2017·5 min read

Disrupted Fat Breakdown in the Brain of Mice Makes Them Dumb

Blocking the breakdown of a specific fat molecule in the the brains of mice lead to reduced learning ability and memory retention. Additionally, researchers noted an increase of Alzheimer's related proteins. Findings may help explain how dementia may develop in humans, researchers say.

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·November 5, 2018·4 min read

Drinking Coffee May Reduce Alzheimer’s and Parkinson’s Risks

According to researchers, drinking coffee could reduce your risk of developing Alzheimer's and Parkinson's disease. The study reports dark roasted coffee appears to have better neuroprotective qualities than light roasts.

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·April 23, 2018·5 min read

Eating More Fish Could Prevent Parkinson’s

Increasing fish consumption could help to lower the risk of developing Parkinson's and other neurodegenerative diseases, researchers report. The study reveals the protein parvalbumin can help to prevent the formation of alpha synuclein.

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·August 12, 2019·3 min read

Estrogen improves Parkinson’s disease symptoms

Selective estrogen treatments appear to reduce symptoms of Parkinson's disease in male mice. The study sheds light on sex-based differences associated with the disease and may provide new therapeutic avenues for treatment.

The image shows an over-sized terminal forms a synapse with a dendritic spine. The caption best describes the image.

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·February 7, 2013·3 min read

Excess Protein Linked to Development of Parkinson’s Disease

Researchers suggest the overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons. The study may have major implications for more fully understanding the causes and mechanisms of Parkinson’s disease.

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