A new study reports people who have a family history of alcohol use disorder release more dopamine in the ventral striatum as a response to the expectation of receiving an alcoholic drink than those without a family history of alcoholism.
Researchers have identified 29 genetic variants linked to problematic alcohol use. Nineteen of the genes were previously unknown independent risk factors for alcohol use disorder.
For those with a genetic predisposition for alcohol use disorder (AUD), being in a romantic relationship appears to reduce the high risk to succumbing to alcohol abuse. This protective effect is limited to males only, suggesting males with a genetic risk for AUD may benefit more from romantic relationships.
Specific neurons in the central nucleus of the amygdala regulate alcohol consumption.
18 genetic variants have been identified which appear to be associated with alcohol use disorder and heavy drinking. Of these genes, five were overlapped, eight were associated with heavy consumption and five were linked to an increased risk of AUD. The study concluded that while heavy drinking is a risk factor for alcoholism, it is not a sufficient cause of the disorder.
Was your New Year's resolution to ditch a bad habit? Researchers explore the best ways to curb your withdrawal and explain why relapse isn't always such a bad thing.
Researchers hypothesize vitamin B1 (thiamine) deficiency may play a significant role in dementia associated with alcohol use disorder. It is known iron deposits in the brain contribute to neurodegenerative diseases. Those with AUD have elevated levels of both iron in their blood and thiamine deficiency. Thiamine is vital for maintaining the blood-brain barrier. Thiamine deficiency associated with AUD disrupts the integrity of the BBB, allowing for more iron deposits within the brain and leading to oxidative tissue damage.
Study reveals a previously unrecognized family connection to alcohol use disorder, the drinking habits of a person's in-laws. People married to those who experienced parental alcohol misuse as a child are more likely to develop an addiction to alcohol, even if the spouse has no history of a personal battle with alcohol use.