Teenage binge drinking is linked to altered gene expression in the brain, specifically the central nucleus of the amygdala. Adolescent rats exposed to alcohol had increased levels of miR-137, resulting in lower expression of proteins essential for healthy neuron growth. During adulthood, these rats displayed higher levels of anxiety and an increased preference for alcohol consumption.
A single shot of ketamine administered to heavy drinkers following reactivation of their drinking memories led to a rapid decrease in the urge to drink. The effect lasted for over nine months.
Specific neurons in the central nucleus of the amygdala regulate alcohol consumption.
Teens with a particular pattern of brain development have an increased frequency of drunkenness, a new study reports. Decreased gray matter density in the frontal and temporal brain regions was associated with an increased risk of teenage over-drinking.
Was your New Year's resolution to ditch a bad habit? Researchers explore the best ways to curb your withdrawal and explain why relapse isn't always such a bad thing.
Using a novel imaging technique, researchers produce a whole mouse brain atlas, which reveals how alcohol addiction, and abstinence, alter the functional architecture of the brain.
Women aged 50 to 70 are more likely to consume alcohol at levels that exceed low-risk drinking guidelines than younger women. They are also more likely to perceive their drinking behavior as normal and acceptable, so long as they appear in control and respectable.
Researchers have identified 29 genetic variants linked to problematic alcohol use. Nineteen of the genes were previously unknown independent risk factors for alcohol use disorder.
Estrogen level fluctuations appear to play a role in alcohol use disorder in women. Reducing the number of estrogen receptors in the ventral tegmental area decreased binge drinking behaviors in female mouse models.
Twenty-nine genes have now been identified as being linked to problematic alcohol use. A new study report, in addition to an increased risk of alcohol use disorder, people with specific genes linked to AUD also have an increased risk of depression, insomnia, and addiction to tobacco.