Study identifies inflammatory mechanisms and cellular activity in the amygdala that drives alcohol addiction in mice. Chronic alcohol exposure compromises immune cells in the brain, driving anxiety and alcohol consumption that may lead to the development of AUD.
Male and female rodents exhibit distinct symptoms and brain features of both PTSD and alcohol use disorder. Following trauma, males show increased GABA receptor function, while females showed increased GABA release.
Optogenetic inactivation of CRF neurons in the central nucleus of the amygdala decreases escalation of alcohol consumption and intensity of withdrawal in rodent models of alcoholism. The findings suggest a potential target for treating excessive drinking in alcohol use disorder.
According to researchers, those who live in colder regions with less daytime sun light drink more alcohol than those who live in warm areas. Climate, researchers say, may impact the prevalence of alcoholism and alcoholic cirrhosis.