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ACE2

Featured Neuroscience Open Neuroscience Articles

·March 23, 2020·2 min read

ACE inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

Researchers confirm ACE inhibitors and ARBS medications may increase the risk of patients with COVID-19 developing more severe symptoms.

This shows covid 19 with a block on the spike

Featured Neuroscience

·March 27, 2020·6 min read

An experimental peptide could block Covid-19

MIT researchers have identified a protein fragment that may inhibit COVID-19's ability to enter human lung cells. The new peptide can bind to the viral protein and potentially disarm it.

Featured Genetics Neuroscience Open Neuroscience Articles

·April 22, 2020·7 min read

Cells in lungs, nasal passage, and intestines more susceptible to COVID-19 infection

Researchers have identified specific cell types that appear to be the main targets of SARS-CoV-2, the virus that causes COVID-19. Using existing data on the RNA found in different types of cells, researchers were able to identify cells that expressed ACE2 and TMPRSS2, two proteins that assist coronavirus to enter human cells. Cells in the lungs, nasal passage and intestines appear to be the main targets for SARS-CoV-2.

Featured Neuroscience Open Neuroscience Articles

·May 1, 2020·4 min read

Coronavirus infects cells of the intestine: Stool samples could be used to test for virus

SARS-CoV-2, the virus that causes COVID-19, can infect intestinal cells and multiple in the gastrointestinal system. When researchers added SARS-CoV-2 to intestinal organoids, they noticed rapid infection. Researchers say in addition to nasal and throat swabs, rectal swabs and stool samples could be key for coronavirus testing.

Featured Genetics Neuroscience

·April 7, 2020·5 min read

Coronavirus receptor abundantly expressed in certain progenitor cells

Certain progenitor cells in the bronchi are mainly responsible for producing coronavirus receptors. These cells normally develop into respiratory tract sells linked with cilia, that clear bacteria out of the lungs.

Featured Neuroscience Open Neuroscience Articles

·May 20, 2020·3 min read

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.

Featured Neuroscience Open Neuroscience Articles

·April 29, 2020·4 min read

COVID-19 study shows that men have over double the death rate of women

Males who contract COVID-19 have 2.5 times the death rate of women. Being males is a significant risk factor for worse disease severity, regardless of age. Researchers found a similar trend in data from the 2003 SARS outbreak. The study speculates the reason why males are more prone to negative outcomes of coronavirus is due to levels of ACE2, which is significantly higher in males than females.

Featured Neuroscience Open Neuroscience Articles

·April 23, 2020·4 min read

Evidence suggests COVID-19 isn’t sexually transmitted

Previous studies report COVID-19 may be present in the testes. Researchers report coronavirus is unlikely to spread via semen, and the chances of the infection being spread through sexual transmission are remote.

Featured Neuroscience

·May 12, 2020·2 min read

Exploring why some COVID-19 patients lose their sense of smell

ACE2 and TMPRSS2, two proteins required for SARS-CoV-2 entry, are produced in cells in the nasal cavity that contribute to odor detection. The findings may explain why people with coronavirus often describe the loss of the sense of smell as a symptom of the virus.

This is a drawing of a man in a facemask

Featured Genetics Neuroscience

·July 24, 2020·7 min read

How COVID-19 Causes Smell Loss

Infection of non-neuronal supporting cells in the nose and forebrain may be responsible for the olfactory problems associated with COVID-19. Findings suggest olfactory sensory neurons are not vulnerable to coronavirus infection as they do not express ACE2.

Featured Neurology Neuroscience

·January 5, 2021·5 min read

How COVID-19 Is Likely to Impact the Brain

Using over a century of data from other pandemics, and applying knowledge about the current COVID-19 infection, researchers predict the long term effects coronavirus will have on the brain and nervous system.

Featured Neuroscience

·April 23, 2020·5 min read

Key nose cells identified as likely COVID-19 virus entry points

The receptor protein ACE2 and the TMPRSS2 protease that can activate SARS-CoV-2 entry are expressed in cells on the inner lining of the nose. Mucus producing goblet cells and ciliated cells in the nose have the highest levels of both proteins, making them the most likely initial infection route for coronavirus. Additional key entry points were found in the cells of the eye's cornea and the intestines. This suggests other points of infection could be via the tear ducts and through fecal-oral transmission.

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ACE2

ACE inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

An experimental peptide could block Covid-19

Cells in lungs, nasal passage, and intestines more susceptible to COVID-19 infection

Coronavirus infects cells of the intestine: Stool samples could be used to test for virus

Coronavirus receptor abundantly expressed in certain progenitor cells

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

COVID-19 study shows that men have over double the death rate of women

Evidence suggests COVID-19 isn’t sexually transmitted

Exploring why some COVID-19 patients lose their sense of smell

How COVID-19 Causes Smell Loss

How COVID-19 Is Likely to Impact the Brain

Key nose cells identified as likely COVID-19 virus entry points

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