LSD increases social behaviors by activating 5-HTPA serotonin receptors and AMPA receptors in the prefrontal cortex, and the mTORC1 protein. Activating all three factors promoted social interactions. The findings suggest supervised LSD microdosing may help alleviate some of the social problems associated with ASD and other mental health disorders that impact social behaviors.
Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic effects of psychedelics for mental health disorders, but without the hallucinations.
Researchers shed new light on why some people may not respond to antidepressants for major depressive disorder. The study reports, neurons in the brains of some with MDD may become hyperactive in the presence of SSRIs.
Researchers report LSD triggers a reduction in functional connection between areas of the brain that govern cognitive processes, while increasing connectivity in brain networks associated with sensory functions.
A new study reveals psychedelics increase dendrites, dendritic spines and synapses, while ketamine may promote neuroplasticity. The findings could help develop new treatments for anxiety, depression and other related disorders.
Researchers explain how SSRI antidepressants initiate action by targeting a specific type of nerve cells. Findings may lead to the development of faster acting antidepressants.
Researchers report the key why LSD hallucinations last so long is due to how it fits into serotonin receptors.