3 Summary: Living less than 50 meters away from a major road, or less than 150 meters away from a highway, increases the risks for dementia, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. However, living close to green spaces appears to have more of a protective effect against neurodegenerative diseases. Source: University of British Columbia Living near major roads or highways is linked to a higher incidence of dementia, Parkinson’s disease, Alzheimer’s disease and multiple sclerosis (MS) suggests new research published this week in the journal Environmental Health. Researchers from the University of British Columbia analyzed data for 678,000 adults in Metro Vancouver. They found that living less than 50 meters from a major road or less than 150 meters from a highway is associated with a higher risk of developing dementia, Parkinson’s, Alzheimer’s and MS–likely due to increased exposure to air pollution. The researchers also found that living near green spaces, like parks, has protective effects against developing these neurological disorders. “For the first time, we have confirmed a link between air pollution and traffic proximity with a higher risk of dementia, Parkinson’s, Alzheimer’s and MS at the population level,” says Weiran Yuchi, the study’s lead author and a PhD candidate in the UBC school of population and public health. “The good news is that green spaces appear to have some protective effects in reducing the risk of developing one or more of these disorders. More research is needed, but our findings do suggest that urban planning efforts to increase accessibility to green spaces and to reduce motor vehicle traffic would be beneficial for neurological health.” Neurological disorders–a term that describes a range of disorders, including Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, and motor neuron diseases–are increasingly recognized as one of the leading causes of death and disability worldwide. Little is known about the risk factors associated with neurological disorders, the majority of which are incurable and typically worsen over time. For the study, researchers analyzed data for 678,000 adults between the ages of 45 and 84 who lived in Metro Vancouver from 1994 to 1998 and during a follow-up period from 1999 to 2003. They estimated individual exposures to road proximity, air pollution, noise and greenness at each person’s residence using postal code data. During the follow-up period, the researchers identified 13,170 cases of non-Alzheimer’s dementia, 4,201 cases of Parkinson’s disease, 1,277 cases of Alzheimer’s disease and 658 cases of MS. For non-Alzheimer’s dementia and Parkinson’s disease specifically, living near major roads or a highway was associated with 14 percent and seven percent increased risk of both conditions, respectively. Due to relatively low numbers of Alzheimer’s and MS cases in Metro Vancouver compared to non-Alzheimer’s dementia and Parkinson’s disease, the researchers did not identify associations between air pollution and increased risk of these two disorders. However, they are now analyzing Canada-wide data and are hopeful the larger dataset will provide more information on the effects of air pollution on Alzheimer’s disease and MS. The researchers also found that living near green spaces, like parks, has protective effects against developing these neurological disorders. Image is in the public domain. When the researchers accounted for green space, they found the effect of air pollution on the neurological disorders was mitigated. The researchers suggest that this protective effect could be due to several factors. “For people who are exposed to a higher level of green space, they are more likely to be physically active and may also have more social interactions,” said Michael Brauer, the study’s senior author and professor in the UBC school of population and public health. “There may even be benefits from just the visual aspects of vegetation.” Brauer added that the findings underscore the importance for city planners to ensure they incorporate greenery and parks when planning and developing residential neighborhoods. The study was co-authored by Hind Sbihi, Hugh Davies, and Lillian Tamburic in the UBC school of population and public health. [divider]About this environmental neuroscience research article[/divider] Source: University of British Columbia Media Contacts: Thandi Fletcher – University of British Columbia Image Source: The image is in the public domain. Original Research: Open access “Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study”. Weiran Yuchi, Hind Sbihi, Hugh Davies, Lillian Tamburic & Michael Brauer . Environmental Health doi:10.1186/s12940-020-0565-4.See alsoFeaturedNeurologyNeuroscience·January 16, 2020Antipsychotics associated with increased risk of head & brain injuries in persons with Alzheimer’s disease Abstract Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study Background Emerging evidence links road proximity and air pollution with cognitive impairment. Joint effects of noise and greenness have not been evaluated. We investigated associations between road proximity and exposures to air pollution, and joint effects of noise and greenness, on non-Alzheimer’s dementia, Parkinson’s and Alzheimer’s disease and multiple sclerosis within a population-based cohort. Methods We assembled administrative health database cohorts of 45–84 year old residents (N ~ 678,000) of Metro Vancouver, Canada. Cox proportional hazards models were built to assess associations between exposures and non-Alzheimer’s dementia and Parkinson’s disease. Given reduced case numbers, associations with Alzheimer’s disease and multiple sclerosis were evaluated in nested case-control analyses by conditional logistic regression. Results Road proximity was associated with all outcomes (e.g. non-Alzheimer’s dementia hazard ratio: 1.14, [95% confidence interval: 1.07–1.20], for living < 50 m from a major road or < 150 m from a highway). Air pollutants were associated with incidence of Parkinson’s disease and non-Alzheimer’s dementia (e.g. Parkinson’s disease hazard ratios of 1.09 [1.02–1.16], 1.03 [0.97–1.08], 1.12 [1.05–1.20] per interquartile increase in fine particulate matter, Black Carbon, and nitrogen dioxide) but not Alzheimer’s disease or multiple sclerosis. Noise was not associated with any outcomes while associations with greenness suggested protective effects for Parkinson’s disease and non-Alzheimer’s dementia. Conclusions Road proximity was associated with incidence of non-Alzheimer’s dementia, Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. This association may be partially mediated by air pollution, whereas noise exposure did not affect associations. There was some evidence of protective effects of greenness. 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