Forever Young: Meditation Might Slow the Age-Related Loss of Gray Matter in the Brain

New brain research findings suggest long-term meditation may lead to less age-related gray matter atrophy in the human brain.

Since 1970, life expectancy around the world has risen dramatically, with people living more than 10 years longer. That’s the good news.

The bad news is that starting when people are in their mid-to-late-20s, the brain begins to wither — its volume and weight begin to decrease. As this occurs, the brain can begin to lose some of its functional abilities.

So although people might be living longer, the years they gain often come with increased risks for mental illness and neurodegenerative disease. Fortunately, a new study shows meditation could be one way to minimize those risks.

Building on their earlier work that suggested people who meditate have less age-related atrophy in the brain’s white matter, a new study by UCLA researchers found that meditation appeared to help preserve the brain’s gray matter, the tissue that contains neurons.

The scientists looked specifically at the association between age and gray matter. They compared 50 people who had mediated for years and 50 who didn’t. People in both groups showed a loss of gray matter as they aged. But the researchers found among those who meditated, the volume of gray matter did not decline as much as it did among those who didn’t.

The article appears in the current online edition of the journal Frontiers in Psychology.

Dr. Florian Kurth, a co-author of the study and postdoctoral fellow at the UCLA Brain Mapping Center, said the researchers were surprised by the magnitude of the difference.

“We expected rather small and distinct effects located in some of the regions that had previously been associated with meditating,” he said. “Instead, what we actually observed was a widespread effect of meditation that encompassed regions throughout the entire brain.”

As baby boomers have aged and the elderly population has grown, the incidence of cognitive decline and dementia has increased substantially as the brain ages.

“In that light, it seems essential that longer life expectancies do not come at the cost of a reduced quality of life,” said Dr. Eileen Luders, first author and assistant professor of neurology at the David Geffen School of Medicine at UCLA. “While much research has focused on identifying factors that increase the risk of mental illness and neurodegenerative decline, relatively less attention has been turned to approaches aimed at enhancing cerebral health.”

Four different images of brain scans are shown.

Brain scans of meditators and non-meditators. Areas of the brain affected by aging (in red) are fewer and less widespread in people who meditate, bottom row, than in people who don’t meditate. Negative correlations between local gray matter and age. Displayed are maximum intensity projections superimposed onto the SPM standard glass brain (sagittal, coronal, axial). Shown, in red, are significant negative age-related correlations within controls (top) and meditators (bottom). Significance profiles are corrected for multiple comparisons via controlling the family-wise error (FWE) rate at p ≤ 0.05. Note the less extended clusters in meditators compared to controls. Credit: Frontiers in Psychology.

Each group in the study was made up of 28 men and 22 women ranging in age from 24 to 77. Those who meditated had been doing so for four to 46 years, with an average of 20 years.

The participants’ brains were scanned using high-resolution magnetic resonance imaging. Although the researchers found a negative correlation between gray matter and age in both groups of people — suggesting a loss of brain tissue with increasing age — they also found that large parts of the gray matter in the brains of those who meditated seemed to be better preserved, Kurth said.

The researchers cautioned that they cannot draw a direct, causal connection between meditation and preserving gray matter in the brain. Too many other factors may come into play, including lifestyle choices, personality traits, and genetic brain differences.

“Still, our results are promising,” Luders said. “Hopefully they will stimulate other studies exploring the potential of meditation to better preserve our aging brains and minds. Accumulating scientific evidence that meditation has brain-altering capabilities might ultimately allow for an effective translation from research to practice, not only in the framework of healthy aging but also pathological aging.”

About this brain research

The research was supported by the Brain Mapping Medical Research Organization, the Robson Family and Northstar Fund, the Brain Mapping Support Foundation, the Pierson?Lovelace Foundation, the Ahmanson Foundation, the Tamkin Foundation, the William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation, the Jennifer Jones?Simon Foundation, the Capital Group Companies Foundation and an Australian Research Council fellowship (120100227). Nicolas Cherbuin of the Australian National University was also an author of the study.

Contact: Mark Wheeler – UCLA
Source: University of California Los Angeles press release
Image Source: Dr. Eileen Luders from research article below.
Original Research: Full open access research for “Forever Young(er): potential age-defying effects of long-term meditation on gray matter atrophy” by Eileen Luders, Nicolas Cherbuin and Florian Kurth in Frontiers in Psychology. Published January 21, 2015. DOI: 10.3389/fpsyg.2014.01551

Abstract:
While overall life expectancy has been increasing, the human brain still begins deteriorating after the first two decades of life and continues degrading further with increasing age. Thus, techniques that diminish the negative impact of aging on the brain are desirable. Existing research, although scarce, suggests meditation to be an attractive candidate in the quest for an accessible and inexpensive, efficacious remedy. Here, we examined the link between age and cerebral gray matter re-analyzing a large sample (n = 100) of long-term meditators and control subjects aged between 24 and 77 years. When correlating global and local gray matter with age, we detected negative correlations within both controls and meditators, suggesting a decline over time. However, the slopes of the regression lines were steeper and the correlation coefficients were stronger in controls than in meditators. Moreover, the age-affected brain regions were much more extended in controls than in meditators, with significant group-by-age interactions in numerous clusters throughout the brain. Altogether, these findings seem to suggest less age-related gray matter atrophy in long-term meditation practitioners.

Full Research Article

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