Researchers from Imperial College London, working with the Beckley Foundation, have for the first time visualised the effects of LSD on the human brain.

In a series of experiments, scientists have gained a glimpse into how the psychedelic compound affects brain activity. The team administered LSD (Lysergic acid diethylamide) to 20 healthy volunteers in a specialist research centre and used various leading-edge and complementary brain scanning techniques to visualise how LSD alters the way the brain works.

The findings, published in Proceedings of the National Academy of Sciences (PNAS), reveal what happens in the brain when people experience the complex visual hallucinations that are often associated with LSD state. They also shed light on the brain changes that underlie the profound altered state of consciousness the drug can produce.

A major finding of the research is the discovery of what happens in the brain when people experience complex dreamlike hallucinations under LSD. Under normal conditions, information from our eyes is processed in a part of the brain at the back of the head called the visual cortex. However, when the volunteers took LSD, many additional brain areas – not just the visual cortex – contributed to visual processing.

Dr Robin Carhart-Harris, from the Department of Medicine at Imperial, who led the research, explained: “We observed brain changes under LSD that suggested our volunteers were ‘seeing with their eyes shut’ – albeit they were seeing things from their imagination rather than from the outside world. We saw that many more areas of the brain than normal were contributing to visual processing under LSD – even though the volunteers’ eyes were closed. Furthermore, the size of this effect correlated with volunteers’ ratings of complex, dreamlike visions. ”

The study also revealed what happens in the brain when people report a fundamental change in the quality of their consciousness under LSD.

Dr Carhart-Harris explained: “Normally our brain consists of independent networks that perform separate specialised functions, such as vision, movement and hearing – as well as more complex things like attention. However, under LSD the separateness of these networks breaks down and instead you see a more integrated or unified brain.

“Our results suggest that this effect underlies the profound altered state of consciousness that people often describe during an LSD experience. It is also related to what people sometimes call ‘ego-dissolution’, which means the normal sense of self is broken down and replaced by a sense of reconnection with themselves, others and the natural world. This experience is sometimes framed in a religious or spiritual way – and seems to be associated with improvements in well-being after the drug’s effects have subsided.”

Dr Carhart-Harris added: “Our brains become more constrained and compartmentalised as we develop from infancy into adulthood, and we may become more focused and rigid in our thinking as we mature. In many ways, the brain in the LSD state resembles the state our brains were in when we were infants: free and unconstrained. This also makes sense when we consider the hyper-emotional and imaginative nature of an infant’s mind.”

In addition to these findings, research from the same group, part of the Beckley/Imperial Research Programme, revealed that listening to music while taking LSD triggered interesting changes in brain signalling that were associated with eyes-closed visions.

In a study published in the journal European Neuropsychopharmacology, the researchers found altered visual cortex activity under the drug, and that the combination of LSD and music caused this region to receive more information from an area of the brain called the parahippocampus. The parahippocampus is involved in mental imagery and personal memory, and the more it communicated with the visual cortex, the more people reported experiencing complex visions, such as seeing scenes from their lives.

PhD student Mendel Kaelen from the Department of Medicine at Imperial, who was lead author of the music paper, said: “This is the first time we have witnessed the interaction of a psychedelic compound and music with the brain’s biology.

The Beckley/Imperial Research Programme hope these collective findings may pave the way for these compounds being one day used to treat psychiatric disorders. They could be particularly useful in conditions where negative thought patterns have become entrenched, say the scientists, such as in depression or addiction.

Mendel Kaelen added: “A major focus for future research is how we can use the knowledge gained from our current research to develop more effective therapeutic approaches for treatments such as depression; for example, music-listening and LSD may be a powerful therapeutic combination if provided in the right way.”

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Image shows brain scans from the study.
The areas that contributed to vision were more active
under LSD, which was linked to hallucinations. Image adapted from the Imperial College press release.

Professor David Nutt, the senior researcher on the study and Edmond J Safra Chair in Neuropsychopharmacology at Imperial, said: “Scientists have waited 50 years for this moment – the revealing of how LSD alters our brain biology. For the first time we can really see what’s happening in the brain during the psychedelic state, and can better understand why LSD had such a profound impact on self-awareness in users and on music and art. This could have great implications for psychiatry, and helping patients overcome conditions such as depression.”

Amanda Feilding, Director of the Beckley Foundation, said: “We are finally unveiling the brain mechanisms underlying the potential of LSD, not only to heal, but also to deepen our understanding of consciousness itself.”

The research involved 20 healthy volunteers – each of whom received both LSD and placebo – and all of whom were deemed psychologically and physically healthy. All the volunteers had previously taken some type of psychedelic drug. During carefully controlled and supervised experiments in a specialist research centre, each volunteer received an injection of either 75 micrograms of LSD, or placebo. Their brains were then scanned using various techniques including fMRI and magnetoencephalography (MEG). These enabled the researchers to study activity within the whole of the brain by monitoring blood flow and electrical activity.

About this neuroscience research

Source: Kate Wighton – Imperial College London
Image Source: The image adapted from the Imperial College press release.
Original Research: Full open access research for “Neural correlates of the LSD experience revealed by multimodal neuroimaging” by Robin L. Carhart-Harris, Suresh Muthukumaraswamy, Leor Roseman, Mendel Kaelen, Wouter Droog, Kevin Murphy, Enzo Tagliazucchi, Eduardo E. Schenberg, Timothy Nest, Csaba Orban, Robert Leech, Luke T. Williams, Tim M. Williams, Mark Bolstridge, Ben Sessa, John McGonigle, Martin I. Sereno, David Nichols, Peter J. Hellyer, Peter Hobden, John Evans, Krish D. Singh, Richard G. Wise, H. Valerie Curran, Amanda Feilding, and David J. Nutt in PNAS. Published online Aprill 11 2016 doi:10.1073/pnas.1518377113


Abstract

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. LSD’s marked effects on the visual cortex did not significantly correlate with the drug’s other characteristic effects on consciousness, however. Rather, decreased connectivity between the parahippocampus and retrosplenial cortex (RSC) correlated strongly with ratings of “ego-dissolution” and “altered meaning,” implying the importance of this particular circuit for the maintenance of “self” or “ego” and its processing of “meaning.” Strong relationships were also found between the different imaging metrics, enabling firmer inferences to be made about their functional significance. This uniquely comprehensive examination of the LSD state represents an important advance in scientific research with psychedelic drugs at a time of growing interest in their scientific and therapeutic value. The present results contribute important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics that inform on how they can model certain pathological states and potentially treat others.

“Neural correlates of the LSD experience revealed by multimodal neuroimaging” by Robin L. Carhart-Harris, Suresh Muthukumaraswamy, Leor Roseman, Mendel Kaelen, Wouter Droog, Kevin Murphy, Enzo Tagliazucchi, Eduardo E. Schenberg, Timothy Nest, Csaba Orban, Robert Leech, Luke T. Williams, Tim M. Williams, Mark Bolstridge, Ben Sessa, John McGonigle, Martin I. Sereno, David Nichols, Peter J. Hellyer, Peter Hobden, John Evans, Krish D. Singh, Richard G. Wise, H. Valerie Curran, Amanda Feilding, and David J. Nutt in PNAS. Published online Aprill 11 2016 doi:10.1073/pnas.1518377113

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  1. very well written article and i agree with the findings, as a frequent user of lsd over 25 years ago i still remember some of the profound thoughts I had and and in some regards made me the person i am today, it could be a useful tool for behavioral reprogramming

  2. Finally! Although we did not have your fancy imaging equipment back in the mid-’60s, there was a great deal of awareness of the potential therapeutic benefits, esp. by researchers at Spring Grove State Mental Hospital in Maryland, where they did a wide variety of experiments with LSD. They did successful cures of alcoholism to the extent that the “cured” person could have a drink without relapsing into addiction. (The failure rates were similar to the rate of patients with “mauve colored urine.” They did creative problem-solving experiments with experts in their fields. Much of this research was included in the first edition (circa 1965) of Masters and Houston’s “The Varieties of the Psychedelic Experience.” You must use the first edition as much of the positive material has since been redacted in later editions for reasons of ‘political correctness.”

    It is a shame that 50 years have been wasted and I am delighted that someone has finally decided to dig into this potentially valuable source of information for researchers and therapy for a wide variety of patients. (For myself, while “under the influence” I quit smoking a two-pack-a-day habit overnight with no desire to begin again.)

  3. LSD has been studied from the 60’s on for the use of psychiatric purposes; mostly in the use for help with addictions and was very effective. There have been other uses in the psychiatric field let alone the stuff the CIA did with the Army for the MK Ultra. I like where I think you are really headed with this. I see where you were saying it was having the affect f having the visual input ether external or internal processed being processed in other area in the brain; which is very similar to Synesthesia and in fact many people who have done LSD reported experiences either very similar or just like Synesthesia.

  4. All I can say is back in the day, when ever I did lsd I was much more intune with life. Even after the trip I felt like I knew what was and is .I have not had that feeling for the last 40 years.
    Bob

  5. I wonder if magic mushrooms have the same effect as lcd on the brain? If the smallest doses can actually trigger a healing property ( has this been tried on someone brain dead ) also if it where as if we had a unconstrained like an infant on lsd , what would happen to the infant mind while in the womb? ( not suggesting it. but you do have to think outside of the box.) from what I’ve seen the brain seems to light up greatly. their has got to be something there? Has it been tried on brain injuries concussions, seizures, dyslexia, and so forth. So many questions.

  6. Good old vitamin L. Why can’t I ever find studies like this to volunteer for? Good job, though, as I could relate a number of experiences I had on LSD that were very interesting, to say the least.

  7. While LSD does provide a more animated state to perception and awareness, like any induced neuro chemical alteration to the brain, the effects though profound are short lived and can induce a subsequent psychic withdrawal. A healthy and enduring endorphin state would be better achieved through a more holistic learning trajectory than what is offered to us as public and private education today. The high stimulus landscape of modern society is a sum total effect of our inability to naturally generate an integrated state of mind. The validation of psychotropic drugs and digital stimulus entertainment, like with tobacco and alcohol before is primarily a symptom of the numbing of our humanity, which to large extent is now a cultural rite of passage and social norm. When profit follows addiction, our ability to move beyond crisis is lost. I could say more and demo a therapeutic alternative, “if” our friends within the research community are truly serious about our societal health above the high.

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