Impaired Kidney Function Linked to Cognitive Disorders

Summary: Of patients with dementia, 7% had chronic kidney disease while 9% had albuminuria, a urinary marker for kidney disease. Chronic kidney disease was associated with a 51% increased risk of developing dementia.

Source: American Society of Nephrology

New research has demonstrated a link between kidney disease and the development of cognitive problems.

The findings will be presented at ASN Kidney Week 2022 November 3–November 6.

The study relied on data from the population-based Framingham Heart Study. Among 2,738 participants without dementia, 187 (7%) had chronic kidney disease and 251 (9%) had albuminuria, a urinary marker of kidney disease.

Albuminuria was associated with signs of silent stroke, and patients with albuminuria had a 65% higher risk of developing mild cognitive impairment or dementia.

This shows the outline of a head
Chronic kidney disease was not associated with markers of silent stroke but was associated with a higher risk of developing dementia. Image is in the public domain

Chronic kidney disease was not associated with markers of silent cerebrovascular disease but was associated with a 51% higher risk of developing dementia.

“Our results highlight the importance of albuminuria as a cerebrovascular and cognitive risk factor and indicate that there may be additional shared disease mechanisms in the kidney and the brain beyond hypertension,” said corresponding author Dearbhla Kelly, MBBChBAO, MSc, DPhil, of St. James’s Hospital, Dublin, Ireland.

About this dementia research news

Author: Christine Feheley
Source: American Society of Nephrology
Contact: Christine Feheley – American Society of Nephrology
Image: The image is in the public domain

Original Research: The findings will be presented at ASN Kidney Week 2022

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