Summary: Following surgery, the brains of children with epilepsy are able to remap and compensate for damaged areas of the visual cortex. The findings shed light on brain plasticity. Source: York University For children with severe epilepsy, surgery is the last resort used to prevent seizures but the treatment can often come with the risk of both visual and cognitive impairments. Now, a new study funded by the National Eye Institute and jointly led by researchers at York University’s Faculty of Health and Carnegie Mellon University, finds that the brains of children with severe epilepsy can compensate by rewiring for missing regions of the visual cortex after surgery. “What we’re seeing is remarkable,” said Erez Freud, assistant professor, Department of Psychology in York University’s Faculty of Health and Centre for Vision Research, co-lead author of the study. “The most striking case in our findings was a 14-year-old girl who had severe epilepsy that originated from the left side of the brain. The part of the brain that was removed in the surgery is known to mediate the ability to read. Despite this hemisphere being removed, this patient could read with relatively normal functioning and when we scanned her brain using the fMRI we found that this ‘reading region’ of the brain had re-mapped to the healthy right hemisphere.” Researchers say this provides strong evidence that the brain has some degree of plasticity. In order for the brain to process visuals normally, it needs to process information sent from the eye and the part of the brain that allows it to understand what the eye is seeing (perception). In order for an individual to see, signals from the eye are first processed in the early visual cortex – a region at the back of the brain that is necessary for sight – and then travel through other parts of the cerebral cortex, to allow recognition of patterns, faces, objects, scenes, and words. In adults, even if sight is still intact, injury or removal of even a small area of the brain’s vision processing centres can lead to dramatic, permanent loss of perception, making them unable to recognize faces or locations, or to read. But in children, who are still developing, this part of the brain seems to have plasticity and is able to rewire itself. Tina Liu, former Ph.D student at Carnegie Mellon University, is co-lead author of the study, and Marlene Behrmann, Professor, Department of Psychology, at Carnegie Mellon University, is senior author. The researchers recruited 10 children who had undergone surgery for severe epilepsy between the ages of six and 17, caused in most cases by an injury such as stroke in infancy or a tumor. The team compared the neural and visuoperceptual profiles of these patients with 10 healthy control children. Three of the children who had gone through a surgery had lost parts of the visual cortex on the right side, three on the left side, and four had lost other parts of the brain not involved in perception, serving as a second kind of control group. Of the six children who had areas of the visual cortex removed, four had permanent reductions in peripheral vision on one side due to loss of the early visual cortex. In each case, the epilepsy was resolved or significantly improved in all children after surgery. In order to better understand how plasticity could be occurring, researchers conducted the study in two phases. In the first phase, each participant was exposed to different series of tasks that tested the children’s perception abilities, including facial recognition, the ability to classify objects, reading, and pattern recognition. They did this by asking the children to identify objects, places and faces. In the second phase, researchers imaged participants’ brains using functional magnetic resonance imaging (fMRI scan). Participants were asked to lie down in the MRI and watch a stream of pictures, words, faces, objects and places. The fMRI allowed researchers to accurately visualize areas in the brain that were activated and measure the response to these pictures. Brains of children with epilepsy are able to re-map after epilepsy surgery to retain visual perception.The image is credited to Erez Freud. With the exception of two individuals who had greater portions of the cortex altered, researchers found all patients showed normal perceptual performance on tasks and were able to identify faces and objects, places and words, falling within the normal range even for complex perception and memory activities. Even in participants who did not show clear remapping, results showed the healthy region of the brain was still able to compensate for missing regions in the hemisphere of the brain where lesions were removed, and in a way not usually seen in adults. Researchers say these findings offer new insights into the malleability of the cortex in children. “It’s possible that early surgical treatment for children with epilepsy might be what allows this re-mapping,” said Freud. “This may be because epilepsy is an on-going condition of the brain and with early removal of the tissue, the brain may have time to rewire itself to the other healthy hemisphere and can therefore compensate for the functions that are impaired in the other part of the brain. But more research is needed to better understand exactly what the developmental processes are that mediate this compensation.”See alsoFeaturedGeneticsNeuroscience·April 9, 2020COVID-19: SARS-CoV-2 mapped out Funding: Freud’s research is currently funded by the Vision: Science to Applications program at York University. [divider]About this neuroscience research article[/divider] Source: York University Media Contacts: Anjum Nayyar – York University Image Source: The image is credited to Erez Freud. Original Research: The findings will be published in Journal of Neuroscience. [divider]Feel free to share this Neuroscience News.[/divider] Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. 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