Summary: Examining microRNA from a simple blood test can help determine whether your child is getting enough sleep.
Source: The Physiological Society
A simple blood test could provide a reliable metric to tell if children are sleeping enough – which is also a marker for general health as sleep affects susceptibility to many diseases – according to new research published in Experimental Physiology this week.
It is commonly recognized that sleep is essential for children’s health, and that insufficient sleep duration is associated with negative health outcomes, such as heart disease and diabetes. In humans, sleep duration and quality are influenced by genetic, environmental and social factors.
Researchers at the Institute of Food Sciences of the National Research Council in Italy studied children and adolescents of normal weight (based on body mass index) from eight European countries (Spain, Italy, Cyprus, Germany, Belgium, Estonia, Hungary and Sweden) who were either “short sleepers” or “normal sleepers,” according to self-reporting.
“Short sleepers” included children sleeping less than 9 hours per day, and adolescents sleeping less than 8 hours per day. “Normal sleepers” included children sleeping at least 9 hours per day, and adolescents sleeping at least 8 hours per day.
They looked at microRNAs in their blood, which are molecules that influence which of our genes are switched on, and found that certain microRNAs had significantly different levels depending on whether the children were short or normal sleepers. The researchers took country of origin, age, sex, pubertal status, average daily screen time, and highest educational level of parents into account, showing that none of these factors was affected the microRNA levels.
These results could provide the basis for a test that could serve not only to assess sleep hygiene, but to determine susceptibility to a range of health conditions. Rather than relying on self-reporting, as we don’t often remember how much we slept farther back than a few days, this blood test could provide a more reliable metric.
Fabio Laura, one of the authors of the study said:
“Our findings show for the first time that the sleep duration reflects the profile of specific circulating microRNAs in school-aged children and adolescents. This could allow clinicians to easily determine if children are sleeping enough by using a simple blood test and use this as an indication of other aspects of their health.”
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Circulating miRNAs are associated with sleep duration in children/adolescents: Results of the I.Family Study
It is commonly recognized that sleep is essential for children’s health, and that insufficient sleep duration is associated with negative health outcomes. In humans, sleep duration and quality are influenced by genetic, environmental and social factors. Epigenetic mechanisms, likewise, regulate circadian rhythms and sleep patterns. In the present study, we aimed to identify circulating microRNAs associated with sleep duration in a subsample of normal‐weight European children/adolescents (n = 111) participating in the I.Family Study. Subjects were divided into two groups based upon self‐reported sleep duration, according to the recommended amount of sleep for paediatric populations. Sleep needs for children <13 years were at least 9 h per day, and for children >13 were at least 8 h per day. There were group differences (short sleepers versus normal sleepers) in circulating levels of miR‐26b‐3p (mean (95% CI) = 2.0 (1.3–2.7) versus 2.3 (1.9–2.7), P = 0.05) and miR‐485‐5p (mean (95% CI) = 0.6 (0.3–0.9) versus 0.9 (0.7 – 1.0), P < 0.001), adjusting for country of origin, age, sex, pubertal status, screen time and highest educational level of parents. Our findings show for the first time that sleep duration reflects the profile of specific circulating microRNAs in school‐aged children and adolescents. It is conceivable that epigenetic modifications, mainly related to circadian rhythm control, may be modulated or interfere with sleep duration.
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