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·June 8, 2026·8 min read

SSRIs Push Serotonin Neurons in Opposite Directions

A new study maps the distinct gene-expression changes induced by fluoxetine inside the brain's primary serotonin hub, the Dorsal Raphe Nucleus.

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·May 22, 2026·10 min read

Serotonin Proven to Reduce Cognitive Belief Stickiness in OCD

Serotonin is a key driver of cognitive flexibility by actively reducing "belief stickiness", the tendency to cling to outdated assumptions despite contradicting real-world evidence.

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·March 16, 2026·7 min read

Acetylcholine Seizes Control of Serotonin Signaling

New research reveals how acetylcholine hijacks the serotonin system, potentially causing the chemical "overdrive" seen in OCD and depression.

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·July 19, 2025·6 min read

More Than Serotonin: How Psychedelics Engage the Whole Brain

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics against over 300 human receptors and found potent activity at serotonin, dopamine, and adrenergic sites.

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·June 11, 2025·4 min read

How Serotonin Circuits Learn from Motion to Regulate Behavior

Scientists have uncovered how serotonergic neurons in larval zebrafish process visual information tied to movement to determine when and how much serotonin to release. This neuromodulator fine-tunes the fish’s swimming effort, adjusting behavior based on the effectiveness of past actions.

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·May 22, 2025·5 min read

DNA Methylation in Serotonin Center Offers New Clues to Autism

A new study has uncovered abnormal DNA methylation patterns in the dorsal raphe—an area of the brain critical for serotonin signaling—in individuals with autism spectrum disorder (ASD). By analyzing postmortem brain samples, researchers identified epigenetic changes in key genes linked to sensory perception, serotonin regulation, and synaptic function.

This shows a brain and a person at a cross roads.

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·April 25, 2025·6 min read

Serotonin Neurons Challenge Old Views of Brain Function

Serotonin neurons in the brainstem are not independent, as once thought, but interact to influence decision-making. Researchers found that clusters of serotonin neurons compete and collaborate, shaping when and how serotonin is released throughout the brain.

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·April 9, 2025·6 min read

Serotonin Helps Your Brain Predict Future Rewards

New research reveals that serotonin plays a key role in how the brain predicts future rewards, shedding light on its puzzling activity in response to both pleasure and pain. Scientists found that serotonin neurons encode a “prospective code for value,” signaling expectations about upcoming outcomes and how rapidly those expectations are changing.

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·April 5, 2025·4 min read

Serotonin Signals the Brain’s Best Guess About Future Rewards

A new study reveals that serotonin neurons in the brain may play a crucial role in helping us estimate the value of future rewards. Rather than simply responding to pleasure or pain, serotonin appears to encode a "prospective value" signal—telling the brain how good the near future is likely to be.

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·March 31, 2025·7 min read

Intermittent Fasting Boosts Male Libido by Lowering Serotonin

A new study shows that long-term intermittent fasting increases the sex drive of male mice by reducing serotonin levels in the brain. The effect was linked to dietary tryptophan deficiency, which lowers the production of serotonin—a neurotransmitter known to inhibit sexual behavior.

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·February 10, 2025·2 min read

Cerebellar Serotonin Acts as a Brake to Reduce Anxiety

New research reveals that serotonin in the cerebellum plays a crucial role in anxiety regulation. Scientists found that mice with lower cerebellar serotonin levels displayed increased anxiety-like behaviors, while those with higher serotonin levels were less anxious.

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·January 8, 2025·6 min read

Dopamine and Serotonin Drive Emotional Word Processing

Researchers have uncovered how neurotransmitters in the brain respond to the emotional content of language, shedding light on the intersection of emotion, cognition, and communication. Using advanced techniques, the team simultaneously measured dopamine, serotonin, and norepinephrine release in patients during exposure to emotionally charged words.