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·July 23, 2026·9 min read

How Midlife Systems Remodeling Reshapes the Human Hippocampus

A new study reveals that the human brain undergoes major shifts in 3D genome architecture and gene regulation starting in midlife.

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·April 9, 2026·8 min read

Virtual Hippocampus: Pinpointing Alzheimer’s “Tipping Points”

Researchers are developing a multiscale model of the hippocampus to identify why specific neurons are vulnerable to Alzheimer's. The virtual testbed aims to find therapeutic tipping points before memory loss becomes irreversible.

The image shows a drawing of a hippocampus.

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·January 29, 2026·5 min read

Hippocampus Predicts Rewards by Reorganizing Memories

Researchers have discovered that the hippocampus isn't just for memory; it acts as a predictive model that shifts neural activity to anticipate rewards, providing new insights into Alzheimer’s.

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·July 15, 2025·3 min read

Hippocampus and Insula Team Up to Encode Emotional Memories

A new study explored how the hippocampus and insula interact during the encoding of emotional memories in humans. Sixteen participants with implanted electrodes viewed emotionally valenced words and attempted to recall them while neural activity was recorded.

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·November 20, 2024·7 min read

Mapping Memory: Unveiling Molecular Signals in the Hippocampus

A recent study uncovers molecular mechanisms driving memory formation in the hippocampus, focusing on mossy fiber synapses. Researchers observed key proteins, Cav2.1 and Munc13, rearrange during memory processing, enhancing synapse precision and power.

This shows a brain and a person playing piano.

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·September 26, 2024·4 min read

Study Links Hippocampus to Control of Skilled Movements

The hippocampus, traditionally linked to memory, also plays a crucial role in skilled actions like typing, handwriting, and playing music. This study challenges the long-held belief that motor skills are exclusively managed by motor regions like the basal ganglia and cerebellum.

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·June 24, 2024·5 min read

Hippocampus Distinguishes Urgent from Future Goals

Researchers discovered how the brain prioritizes immediate and distant goals. Their study found that the hippocampus processes urgent goals faster and differently than future goals. This insight could help understand psychiatric disorders like depression, which affect goal-setting abilities. The findings reveal crucial differences in brain activity and behavior related to goal prioritization.

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·April 10, 2024·4 min read

Hippocampus Generates Deep Sleep Waves

Scientists discovered a surprising new source for brain waves essential for deep sleep. These waves, traditionally thought to come from a different area, were also found to be generated by the hippocampus, a region crucial for memory.

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·November 15, 2023·2 min read

Hippocampus Shrinkage Linked to Cognitive Decline Beyond Alzheimer’s

A new study indicates that hippocampal shrinkage in the brain is associated with cognitive decline, independent of amyloid-beta plaques, a key marker of Alzheimer's disease. The study suggests that neurodegenerative diseases other than Alzheimer's contribute to cognitive decline.

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·November 1, 2023·5 min read

Metabolic Rise in Hippocampus Unveils Alzheimer’s Early Footprint

Researchers reveal a surprising early phase in Alzheimer’s disease development: a metabolic boost in the hippocampus. Studying mice resembling human Alzheimer's pathology, they observed increased mitochondrial metabolism followed by synaptic disruptions due to hindered cellular recycling.

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·October 23, 2023·6 min read

Unlocking the Dual Memory Codes of the Hippocampus

Researchers have distinguished between two vital memory tasks housed in the hippocampus: one that remembers associations and another that predicts based on past events. The study used optogenetics to isolate one memory function without affecting the other.

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·October 2, 2023·6 min read

Hidden in the Hippocampus are the Neural Secrets Behind False Memories

Neuroscientists delved into the mechanisms behind true and false memories. Their study reveals that electrical signals in the hippocampus can differentiate between the imminent recall of authentic versus fabricated memories.