Study Sheds Light On the Role of Proteins and How Synapses Work

Summary: Study could shed light on role of synapse function in the diagnosis and treatment of neurodegenerative diseases.

Source: University of Plymouth.

The findings of the study will prove invaluable to other research studies examining the role of synapse function in the diagnosis and treatment of neurodegenerative and other diseases.

Synapses are the power junctions that allow living creatures to function. Popularly associated with learning and memory, they play a more fundamental role in our existence by regulating everything from breathing, sleeping and waking and other bodily functions.

Loss of synapses and synapse function sit at the heart of a number of diseases, not just neurodegenerative examples such as dementia and Parkinson’s disease but also conditions such as diabetes. We do not fully understand how synapses work, but new research published on Nature Neuroscience‘s website has shed new light on the role of proteins in the way in which synapses maintain their signalling.

The research has been carried out by an international team of scientists from: the Institute for Biology/Genetics and the Institute of Chemistry and Biochemisty/Structural Biochemistry, Freie Universität Berlin; NeuroCure, Cluster of Excellence, Charité Universitätsmedizin, Berlin; Molecular and Theoretical Neuroscience, Leibniz-Institut für Molekulare Pharmakologie, Berlin; Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen; Plymouth University Peninsula Schools of Medicine and Dentistry; the Department of Genetics, University of Cambridge, and; the Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Austria.

The team used genetics like a scalpel blade to remove individual proteins from the synapse to identify their different roles within the synapse, and how they maintain synaptic transmission. They used synapses from the fruit fly drosophila, which compares remarkably closely to synapses in humans.

The team used genetics like a scalpel blade to remove individual proteins from the synapse to identify their different roles within the synapse, and how they maintain synaptic transmission. They used synapses from the fruit fly drosophila, which compares remarkably closely to synapses in humans.

Diagram of a synapse.
The findings of the study will prove invaluable to other research studies examining the role of synapse function in the diagnosis and treatment of neurodegenerative and other diseases. NeuroscienceNews.com image is for illustrative purposes only.

The results showed that two variations of a protein called Unc13 work separately to regulate synaptic transmission. The study is the first to show how the different forms of this protein work.

The findings of the study will prove invaluable to other research studies examining the role of synapse function in the diagnosis and treatment of neurodegenerative and other diseases. A greater understanding of how synapses work may also find a role in identifying unexpected drug targets for specific diseases.

Dr. Iain Robinson, Associate Professor in Neurosciences at Plymouth University Peninsula Schools of Medicine and Dentistry is part of the international research team on this study. He said: “Using a combination of genetics and state of the art imaging allows us to dissect the function of synapses which are used to convey messages in the brain. We have moved another step nearer to understanding the mechanisms employed by synapses and created knowledge which could play a vital role in research projects with the potential to discover breakthroughs in the diagnosis and treatment of a wide range of debilitating and life-changing diseases.”

About this neuroscience research article

Source: Andrew Gould – University of Plymouth
Image Source: This NeuroscienceNews.com image is in the public domain.
Original Research: The study will appear in Nature Neuroscience during the week of August 15, 2016.

Cite This NeuroscienceNews.com Article

[cbtabs][cbtab title=”MLA”]University of Plymouth. “Study Sheds Light On the Role of Proteins and How Synapses Work.” NeuroscienceNews. NeuroscienceNews, 15 August 2016.
<https://neurosciencenews.com/synapses-proteins-neuroscience-4844/>.[/cbtab][cbtab title=”APA”]University of Plymouth. (2016, August 15). Study Sheds Light On the Role of Proteins and How Synapses Work. NeuroscienceNews. Retrieved August 15, 2016 from https://neurosciencenews.com/synapses-proteins-neuroscience-4844/[/cbtab][cbtab title=”Chicago”]University of Plymouth. “Study Sheds Light On the Role of Proteins and How Synapses Work.” https://neurosciencenews.com/synapses-proteins-neuroscience-4844/ (accessed August 15, 2016).[/cbtab][/cbtabs]

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