Scientists show that SR-3306 delivered orally to mice and rat models of Parkinson's disease was able to protect brain cells from neurodegeneration. SR-3306 inhibits the c-jun-N-terminal kinases (JNK) class of enzymes, previously shown to play large roles in neuron survival.
Neuroscience researchers have identified a new molecular pathway underlying Parkinson's disease. The pathway involves polyamines, which were discovered to be responsible for increased build-up of other toxic proteins in neurons. The research also suggests polyamine lowering drugs could have a protective effect from Parkinson's disease.