Scientists have long believed that glioblastoma multiforme, the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. Researchers found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.
U-M scientists stop abnormal brain cell growth in mice with neurofibromatosis using experimental tumor drug, make new discoveries in neural stem cells.
Scientists showed in mice that disabling a gene linked to a common pediatric tumor disorder, neurofibromatosis type 1 (NF1), made stem cells from one part of the brain proliferate rapidly. But the same genetic deficit had no effect on stem cells from another brain region.
Genetic Manipulation Boosts Growth of Brain Cells Linked to Learning, Enhances Effects of Antidepressants
Southwestern Medical Center investigators have identified a genetic manipulation that increases the development of neurons in the brain during aging and enhances the effect of antidepressant drugs. The research finds that deleting the Nf1 gene in mice results in long-lasting improvements in neurogenesis, which in turn makes those in the test group more sensitive to the [...]
Neurobiology research from UCLA indicates the possibility of GABA interfering with working memory in patients with neurofibromatosis type 1, or NF1.