Researchers work to understand how expanded polyglutamine tracts form the types of supramolecular structures that are presumed to be toxic to neurons.
Researchers have developed a new way in which to measure the shape of the huntingtin protein in living cells.
A new study indicates that quickly clearing away defective proteins in the brain could help prevent some neurodegenerative disorders.
Researchers discover a three molecule complex could be a target for treating Huntington’s Disease, a genetic and currently incurable brain disease which causes movement disorders and dementia.
A new light-based technique for measuring levels of the toxic protein that causes Huntington’s disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.
HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.
‘HD in a dish’ will facilitate search for elusive treatment. An international consortium of Huntington’s disease experts, including several from the Sue and Bill Gross Stem Cell Research Center at UC Irvine, has generated a human model of the deadly inherited disorder directly from the skin cells of affected patients. The re-created neurons, which live […]