Using neuroimaging, researchers discovered glutamate levels are abnormally high in people with restless leg syndrome. The higher the level of glutamate in patients with RLS, the less sleep they were able to get.
Researchers upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons. The study describes how a compound linked to Alzheimer’s disease impacts NMDA receptors and weakens synaptic connections between brain cells.
Scientists have now identified a specific dysfunction in neuronal circuits that is caused by autism. The scientists also report about their success in reversing these neuronal changes in mouse models.
Boosts Sociability, Quells Repetitiveness – NIH Study National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say. [...]
A recent study finds that a new compound reverses many of the major symptoms associated with Fragile X syndrome (FXS), the most common form of inherited intellectual disability and a leading cause of autism. The paper, published by Cell Press in the April 12 issue of the journal Neuron, describes the exciting observation that the [...]