FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·April 19, 2022·4 min readResearch Team Affirms Useful Blood Biomarker for Group of Brain Disorders in New StudyStudy confirms neurofilament light is a useful blood-based biomarker for frontotemporal dementia, PSP, and primary progressive aphasia.Read More
FeaturedNeurologyNeuroscience·April 7, 2022·4 min readBrainstem Atrophy Is Linked to Extrapyramidal Symptoms in Frontotemporal DementiaPatients who suffer from frontotemporal dementia with extrapyramidal symptoms have brainstem atrophy and reduced metabolic activity in specific brain regions compared to those with FTD without extrapyramidal symptoms.Read More
FeaturedNeurologyNeuroscience·March 10, 2022·4 min readMotor Neuron Toxin Associated With ALS IdentifiedPolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.Read More
FeaturedNeurologyNeuroscience·March 8, 2022·5 min readDementia Patients Struggle to Cope With Change Because of Damage to General Intelligence Brain NetworksDamage to the multiple demand network, a brain network associated with general intelligence, causes people with dementia to struggle to adapt to changes in their environmentRead More
FeaturedGeneticsNeurologyNeuroscience·February 28, 2022·4 min readA New Molecular Pathway Shared by Two Neurodegenerative Disorders DiscoveredMislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.Read More
FeaturedNeurologyNeuroscience·July 26, 2021·5 min readEarly Signs of Frontotemporal Dementia Found in Personalized Cerebral OrganoidsResearchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.Read More
FeaturedNeurologyNeuroscience·July 20, 2021·4 min readSpinal Fluid Biomarkers Detect Neurodegeneration and Alzheimer’s Disease in Living PatientsResearchers report Alzheimer's disease and other neurodegenerative disorders can be confirmed in living patients by specific biomarkers in cerebrospinal fluid.Read More
FeaturedGeneticsNeurologyNeuroscience·July 8, 2021·4 min readALS: Study Shows Role of Brain’s Immune CellsHyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.Read More
FeaturedNeurologyNeuroscience·June 7, 2021·6 min readSimple Blood Test Can Accurately Reveal Underlying NeurodegenerationNfL, a single biomarker in the blood, can accurately predict the presence of underlying neurodegenerative disorders, such as FTD and ALS, in people with cognitive problems.Read More
FeaturedNeurologyNeurosciencePsychology·April 12, 2021·5 min readProfound Loss of Pleasure Related to Early-Onset DementiaStudy links anhedonia, or the loss of pleasure, to the early onset of frontotemporal dementia. Neuroimaging revealed symptoms of anhedonia were marked by atrophy in the frontal and striatal brain areas of those with FTD.Read More
FeaturedGeneticsNeurologyOpen Neuroscience Articles·March 19, 2021·3 min readGenetic Pathway That Suppresses ALS IdentifiedThe LSM12-EPAC1 pathway is an important suppressor of the NCT-related pathologies associated with ALS and FTD.Read More
FeaturedNeurologyNeuroscience·February 17, 2021·3 min readWhite Matter Changes in Brain Found in Frontotemporal DementiaStudy reveals those with frontotemporal dementia have greater white matter hyperintensity than those with other forms of dementia. The amount of white matter hyperintensity was associated with the severity of FTD symptoms.Read More