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Alzheimer’s disease

·November 19, 2025·7 min read

Lithium Fails to Slow Cognitive Decline in Alzheimer’s

A new meta-analysis of six randomized controlled trials shows that lithium supplementation does not significantly slow cognitive decline in people with mild cognitive impairment or Alzheimer’s disease. While preclinical evidence suggests lithium supports resilience against amyloid and tau pathology, these benefits failed to translate to clinical outcomes using traditional lithium salts.

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·November 12, 2025·5 min read

Alzheimer’s Drug Reduces Amyloid but Fails to Restore Brain Waste Flow

Researchers found that lecanemab, the Alzheimer’s drug designed to clear amyloid-β plaques, does not improve the brain’s waste clearance system in the short term. In a three-month study using MRI-based DTI-ALPS imaging, scientists observed no measurable recovery in glymphatic function after treatment.

This shows a family and the face of an older woman.

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·November 10, 2025·7 min read

Why Alzheimer’s Patients Forget Loved Ones

Researchers have discovered that the heartbreaking moment when a person with Alzheimer’s no longer recognizes family may stem from the breakdown of perineuronal nets, protective structures that support social memory. In mice, the loss of these nets erased memory of familiar individuals while sparing object memory, mirroring early human symptoms.

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·November 5, 2025·6 min read

Your Neighborhood Could Influence Your Risk of Dementia

Researchers found that living in a socioeconomically deprived neighborhood can harm brain health as early as midlife. People from these areas showed more signs of small-vessel brain damage, slower thinking skills, and poorer control of lifestyle factors such as blood pressure, obesity, and sleep.

Featured Neurology Neuroscience

·November 5, 2025·5 min read

Brain’s Immune Cells Found to Protect Against Alzheimer’s Damage

Researchers have uncovered how the brain’s immune cells, called microglia, can act as protectors rather than destroyers in Alzheimer’s disease. By lowering the immune regulator PU.1, microglia began expressing lymphoid-like receptors that reduced inflammation and preserved cognitive function in mouse models.

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·October 24, 2025·7 min read

Alzheimer’s Disrupts Brain’s Internal Clock, Unraveling Gene Rhythms

Alzheimer’s disease not only damages memory but also distorts the brain’s internal clock, disrupting the daily rhythms of hundreds of genes tied to brain health. Researchers found that in mice with amyloid buildup, normal circadian gene activity in microglia and astrocytes—the brain’s immune and support cells—became erratic.

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·October 17, 2025·5 min read

New Alzheimer’s Mutation Weakens Brain’s Immune Defense

A new study has identified a mutation in the TREM2 gene that disrupts the brain’s ability to clear toxic amyloid plaques, increasing Alzheimer’s disease risk. The mutation, called T96K, keeps the TREM2 gene in an overactive state that paradoxically weakens microglial “cleanup” activity, especially in females.

Featured Neurology Neuroscience

·October 16, 2025·5 min read

Where You Live Could Shape Your Brain and Dementia Risk

New research shows that neighborhood conditions — from pollution and housing to economic opportunity — may directly affect brain health and dementia risk. Analyzing brain scans and biomarkers from 679 adults, scientists found that people living in areas with higher social and environmental disadvantages showed signs of reduced brain thickness, altered blood flow, and white matter changes.

Featured Neurology Neuroscience

·October 9, 2025·6 min read

Lifelong Social Bonds Keep the Aging Brain Sharp and Flexible

Rats that lived in social groups throughout their lives retained youthful memory and mental flexibility well into old age, according to new research. Even with equal physical stimulation, only socially connected rats performed as well as younger ones on complex memory tests, while isolated rats showed significant decline.

This shows a brain and a woman holding supplements.

Featured Neurology Neuroscience

·October 7, 2025·6 min read

Calcium Supplements Do Not Raise Dementia Risk

A long-term study of more than 1,400 older women found no evidence that calcium supplements increase dementia risk, easing previous concerns about their safety. Conducted over 14.5 years, the research compared women taking calcium monotherapy to those given a placebo and found no difference in cognitive outcomes.

Featured Neurology Neuroscience

·October 6, 2025·6 min read

Brain’s Shape Could Reveal the Earliest Signs of Alzheimer’s

A groundbreaking study reveals that aging alters not just the size but the shape of the human brain, reshaping regions in ways linked to memory and reasoning decline. Researchers found that as people age, the lower and front areas of the brain expand outward, while the upper and back regions compress inward.

Featured Neurology Neuroscience

·October 2, 2025·4 min read

Tiny Fat Messengers May Link Obesity to Alzheimer’s Plaque Buildup

A groundbreaking study reveals how obesity may drive Alzheimer’s disease through tiny messengers called extracellular vesicles released from fat tissue.