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Brain Size Mediates the Association Between Height and Cognitive Ability

Summary: Researchers have identified a link between cortical surface area, height and cognitive ability. The study reports taller people have bigger cortices, which in turn is linked to better cognitive function.

Source: University of Helsinki.

Reports from several studies have identified a link between height and general cognitive ability, or intelligence, but the mechanisms underlying this association are not well known. Researchers from the University of Helsinki, University of California San Diego and Boston University found that this association is mediated by cortical surface area.

The researchers examined the association between height and cognition through a model where the size of cortical grey matter was considered as a mediator. They found that greater height was associated with bigger cortex, which in turn was linked with better cognitive ability.

“Even though taller individuals have, on average, bigger brain compared to shorter people, the size of any given individual’s brain cannot be determined by their stature alone. Further, cognitive ability is not simply determined by brain size,” says the corresponding author of the research article Eero Vuoksimaa from the University of Helsinki.

“The findings do, however, shed light on the biological mechanism underlying the association between height and cognition.”

In the study, cortical grey matter was measured with magnetic resonance imaging (MRI). The focus was on the total cortical surface area and mean cortical thickness. According to the findings, total surface area was bigger in taller persons, whereas height was not related to cortical thickness.

“These observations are in line with recent MRI studies of cortical development suggesting that cortical surface area increases until approximately the age of 12, whereas thinning of cortex occurs across the childhood and adolescence,” notes Vuoksimaa.

people

In the study, cortical grey matter was measured with magnetic resonance imaging (MRI). The focus was on the total cortical surface area and mean cortical thickness. According to the findings, total surface area was bigger in taller persons, whereas height was not related to cortical thickness. NeuroscienceNews.com image is adapted from the University of Helsinki news release.

The study participants were 51-60 year old American men. The researchers note that even though genetic effects accounted for most of the individual differences in height, cortical size and cognition, the contribution of environmental factors may be much larger in other populations.

“For example, childhood malnutrition has an impact on both height and brain growth, and affects also cognitive development,” reminds Vuoksimaa.

In the study, cognitive ability was measured with a paper-and-pencil test consisting of items measuring verbal, mathematical, spatial and reasoning abilities.

About this neuroscience research article

Source: Eero Vuoksimaa – University of Helsinki
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is adapted from the University of Helsinki news release.
Original Research: Abstract for “Brain structure mediates the association between height and cognitive ability” by Eero Vuoksimaa, Matthew S. Panizzon, Carol E. Franz, Christine Fennema-Notestine, Donald J. HaglerJr., Michael J. Lyons, Anders M. Dale, and William S. Kremen in Brain Structure and Function. Published May 11 2018.
doi:10.1007/s00429-018-1675-4

Cite This NeuroscienceNews.com Article
University of Helsinki “Brain Size Mediates the Association Between Height and Cognitive Ability.” NeuroscienceNews. NeuroscienceNews, 14 May 2018.
<http://neurosciencenews.com/height-cognition-brain-size-9041/>.
University of Helsinki (2018, May 14). Brain Size Mediates the Association Between Height and Cognitive Ability. NeuroscienceNews. Retrieved May 14, 2018 from http://neurosciencenews.com/height-cognition-brain-size-9041/
University of Helsinki “Brain Size Mediates the Association Between Height and Cognitive Ability.” http://neurosciencenews.com/height-cognition-brain-size-9041/ (accessed May 14, 2018).

Abstract

Brain structure mediates the association between height and cognitive ability

Height and general cognitive ability are positively associated, but the underlying mechanisms of this relationship are not well understood. Both height and general cognitive ability are positively associated with brain size. Still, the neural substrate of the height-cognitive ability association is unclear. We used a sample of 515 middle-aged male twins with structural magnetic resonance imaging data to investigate whether the association between height and cognitive ability is mediated by cortical size. In addition to cortical volume, we used genetically, ontogenetically and phylogenetically distinct cortical metrics of total cortical surface area and mean cortical thickness. Height was positively associated with general cognitive ability and total cortical volume and cortical surface area, but not with mean cortical thickness. Mediation models indicated that the well-replicated height-general cognitive ability association is accounted for by individual differences in total cortical volume and cortical surface area (highly heritable metrics related to global brain size), and that the genetic association between cortical surface area and general cognitive ability underlies the phenotypic height-general cognitive ability relationship.

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