Summary: According to researchers, the visual environment a zebrafish matures in affects their spontaneous brain activity.
Source: University of Queensland.
How different experiences early in life affect spontaneous brain activity and an individual’s behavior.
It’s said to be a “lightbulb” moment – when an idea pops into your head.
The adult human brain often displays this kind of spontaneous activity – and University of Queensland experts have uncovered how different experiences early in life might affect the nature of that activity and, in turn, alter an individual’s behaviour.
Study leader Professor Geoffrey Goodhill, from the Queensland Brain Institute and the School of Mathematics and Physics, used zebrafish as a model to investigate the origins of spontaneous neural activity – in the form of new thoughts.
“We wanted to observe the fishes’ spontaneous brain patterns to see if their environment had an impact on the way their brains wired up.”
The researchers found that spontaneous activity in the part of the brain that processes visual images peaked when the zebrafish were five days old, and then declined.
“Zebrafish in the larvae phase are transparent, so we can directly image their neural activity,” said Professor Goodhill, whose team included researchers from the UQ School of Mathematics and Physics and the UQ School of Biomedical Sciences.
“We then used a branch of mathematics called graph theory to analyse the resulting patterns.”
The study found the visual environment the fish grew up in affected their spontaneous brain activity.
Turning off the lights while the larvae developed – known as “dark rearing” – changed their brains’ patterns of spontaneous activity.
“One of the most interesting results was that dark rearing also reduced the larvae’s ability to catch their prey, a single-celled organism called paramecia, even after the lights were turned back on,” said Professor Goodhill.
“This shows that the environment affects the way the zebrafish brain becomes wired up as it grows, and this wiring change affects the fish’s behaviour.
“It’s very exciting that there is a lot more brain plasticity in the zebrafish brain than we previously realised.
“This means that zebrafish can perhaps help us understand what happens to the brains of people who are deprived of the right kinds of input early in life.”
The team now plans to investigate whether there are certain moments during the zebrafish’s early life when the right input is particularly critical for brain development, as has been shown in humans.
The study, ‘Spontaneous activity in the zebrafish tectum reorganizes over development and is influenced by visual experience’, is published in the journal Current Biology.
Source: Andrea Markey – University of Queensland
Image Source: NeuroscienceNews.com image is credited to G. Goodhill/Queensland Brain Institute.
Original Research: Abstract for “Spontaneous Activity in the Zebrafish Tectum Reorganizes over Development and Is Influenced by Visual Experience” by Lilach Avitan, Zac Pujic, Jan Mölter, Matthew Van De Poll, Biao Sun, Haotian Teng, Rumelo Amor, Ethan K. Scott, and Geoffrey J. Goodhill in Current Biology. Published online August 3 2017 doi:10.1016/j.cub.2017.06.056
[cbtabs][cbtab title=”MLA”]University of Queensland “How Early Life Experiences Affect the Adult Brain.” NeuroscienceNews. NeuroscienceNews, 3 August 2017.
<early-experience-neurodevelopment-7234/>.[/cbtab][cbtab title=”APA”]University of Queensland (2017, August 3). How Early Life Experiences Affect the Adult Brain. NeuroscienceNew. Retrieved August 3, 2017 from early-experience-neurodevelopment-7234/[/cbtab][cbtab title=”Chicago”]University of Queensland “How Early Life Experiences Affect the Adult Brain.” early-experience-neurodevelopment-7234/ (accessed August 3, 2017).[/cbtab][/cbtabs]
Abstract
Spontaneous Activity in the Zebrafish Tectum Reorganizes over Development and Is Influenced by Visual Experience
Highlights
•Calcium imaging of zebrafish optic tectum every day from 4 to 9 dpf
•Graph measures derived from spontaneous activity change over development
•Neural assemblies change their properties over development
•Spontaneous activity and behavior are affected by visual experience
Summary
Spontaneous patterns of activity in the developing visual system may play an important role in shaping the brain for function. During the period 4–9 dpf (days post-fertilization), larval zebrafish learn to hunt prey, a behavior that is critically dependent on the optic tectum. However, how spontaneous activity develops in the tectum over this period and the effect of visual experience are unknown. Here we performed two-photon calcium imaging of GCaMP6s zebrafish larvae at all days from 4 to 9 dpf. Using recently developed graph theoretic techniques, we found significant changes in both single-cell and population activity characteristics over development. In particular, we identified days 5–6 as a critical moment in the reorganization of the underlying functional network. Altering visual experience early in development altered the statistics of tectal activity, and dark rearing also caused a long-lasting deficit in the ability to capture prey. Thus, tectal development is shaped by both intrinsic factors and visual experience.
“Spontaneous Activity in the Zebrafish Tectum Reorganizes over Development and Is Influenced by Visual Experience” by Lilach Avitan, Zac Pujic, Jan Mölter, Matthew Van De Poll, Biao Sun, Haotian Teng, Rumelo Amor, Ethan K. Scott, and Geoffrey J. Goodhill in Current Biology. Published online August 3 2017 doi:10.1016/j.cub.2017.06.056
