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Mapping the Brain’s Aging Connections

Summary: Researchers report the brain connections that are key to cognition and complex thinking skills are most effected as we age.

Source: University of Edinburgh.

Impact of ageing on brain connections mapped in major scan study.

Brain connections that play a key role in complex thinking skills show the poorest health with advancing age, new research suggests.

Connections supporting functions such as movement and hearing are relatively well preserved in later life, the findings show.

Scientists carrying out the most comprehensive study to date on ageing and the brain’s connections charted subtle ways in which the brain’s connections weaken with age.

Knowing how and where connections between brain cells – so-called white matter – decline as we age is important in understanding why some people’s brains and thinking skills age better than others.

Worsening brain connections as we age contribute to a decline in thinking skills, such as reasoning, memory and speed of thinking.

Researchers from the University of Edinburgh analysed brain scans from more than 3,500 people aged between 45 and 75 taking part in the UK Biobank study.

Researchers say the data will provide more valuable insights into healthy brain and mental ageing, as well as making contributions to understanding a range of diseases and conditions.

The study was published in Nature Communications journal.

Dr Simon Cox, of the University of Edinburgh’s Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), who led the study, said: “By precisely mapping which connections of the brain are most sensitive to age, and comparing different ways of measuring them, we hope to provide a reference point for future brain research in health and disease.

“This is only one of the first of many exciting brain imaging results still to come from this important national health resource.”

Professor Ian Deary, Director of CCACE, said: “Until recently, studies of brain scans with this number of people were not possible. Day by day the UK Biobank sample grows, and this will make it possible to look carefully at the environmental and genetic factors that are associated with more or less healthy brains in older age.”

Professor Paul Matthews of Imperial College London, Chair of the UK Biobank Expert Working Group, who was not involved in the study, said: “This report provides an early example of the impact that early opening of the growing UK Biobank Imaging Enhancement database for access by researchers world-wide will have.

Image shows brain scans.

This image shows how ageing affects the health of most white matter pathways with age, but some more strongly than others. NeuroscienceNews image is adapted from the University of Edinburgh press release.

“The large numbers of subjects in the database has enabled the group to rapidly characterise the ways in which the brain changes with age – and to do so with the confidence that large numbers of observations allow.

“This study highlights the feasibility of defining what is typical, to inform the development of quantitative MRI measures for decision making in the clinic.”

About this neuroscience research article

Funding: The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology receives funding from the Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council (BBSRC).

UK Biobank was established by the Wellcome Trust, MRC, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. UK Biobank is hosted by the University of Manchester and supported by the NHS.

Source: Joanne Morrison – University of Edinburgh
Image Source: NeuroscienceNews.com image is adapted from the University of Edinburgh press release.
Original Research: Full open access research for “Ageing and brain white matter structure in 3,513 UK Biobank participants” by Simon R. Cox, Stuart J. Ritchie, Elliot M. Tucker-Drob, David C. Liewald, Saskia P. Hagenaars, Gail Davies, Joanna M. Wardlaw, Catharine R. Gale, Mark E. Bastin & Ian J. Deary in Nature Communications. Published online December 15 2016 doi:10.1038/NCOMMS13629

Cite This NeuroscienceNews.com Article
University of Edinburgh. “Mapping the Brain’s Aging Connections.” NeuroscienceNews. NeuroscienceNews, 17 December 2016.
<http://neurosciencenews.com/aging-connections-neuroscience-5769/>.
University of Edinburgh. (2016, December 17). Mapping the Brain’s Aging Connections. NeuroscienceNews. Retrieved December 17, 2016 from http://neurosciencenews.com/aging-connections-neuroscience-5769/
University of Edinburgh. “Mapping the Brain’s Aging Connections.” http://neurosciencenews.com/aging-connections-neuroscience-5769/ (accessed December 17, 2016).

Abstract

Ageing and brain white matter structure in 3,513 UK Biobank participants

Quantifying the microstructural properties of the human brain’s connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64–77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely studied indices from neurite orientation dispersion and density imaging, we document large age associations with white matter microstructure. Mean diffusivity is the most age-sensitive measure, with negative age associations strongest in the thalamic radiation and association fibres. White matter microstructure across brain tracts becomes increasingly correlated in older age. This may reflect an age-related aggregation of systemic detrimental effects. We report several other novel results, including age associations with hemisphere and sex, and comparative volumetric MRI analyses. Results from this unusually large, single-scanner sample provide one of the most extensive characterizations of age associations with major white matter tracts in the human brain.

“Ageing and brain white matter structure in 3,513 UK Biobank participants” by Simon R. Cox, Stuart J. Ritchie, Elliot M. Tucker-Drob, David C. Liewald, Saskia P. Hagenaars, Gail Davies, Joanna M. Wardlaw, Catharine R. Gale, Mark E. Bastin & Ian J. Deary in Nature Communications. Published online December 15 2016 doi:10.1038/NCOMMS13629

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